More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitroArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 치료법, 치료제, [키워드] ACE2 receptor Analysis Antiviral antiviral genes antiviral response antiviral therapy can be used Cell cell line cells Combination competent Complete coronavirus Coronavirus replication CXCL10 cytidylic acid double-stranded expand fibroblast Gene Expression HCoV-229E HCoV-NL63 help Human human coronavirus human coronaviruses human lung IFN IFNs IFNβ in vitro increase in inducer Infection inhibit innate immune interferons ISG15 limit MERS-CoV Nanoparticles Pathogens Poly I:C. post infection PROTECT provided required SARS-CoV-2 SARS-CoV-2 pandemic stimulate translated Treatment Type I IFN type I interferon virus production were infected while [DOI] 10.1016/j.virusres.2022.198925 PMC 바로가기
Role of aging in Blood-Brain Barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19혈액-뇌장벽 기능 장애 및 SARS-CoV-2 감염에 대한 감수성에서 노화의 역할: COVID-19의 신경학적 증상에 대한 영향Review Published on 2022-08-182022-09-11 Journal: Fluids and Barriers of the CNS [Category] SARS, 치료기술, 치료제, [키워드] addition age aging alleviate astrocytes barrier blood-brain barrier Brain caused cell type Central nervous system cerebrospinal fluid CNS Comorbidity Corona Corona virus COVID-19 COVID-19 patients Cytokine storm deaths described diabete diabetes distress dysfunction endothelial cells endothelial function expression profile Hospitalization Impact inducer inflammatory reaction inflammatory reactions Interaction interactome microglia Mitochondria mitochondrial Mitochondrial function mitochondrial functions morbidity and mortality neurological Neurological symptom Neurological symptoms neurons Neurovascular outcome patients pericytes Pneumonia present respiratory respiratory distress risk factor role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 receptors Severe acute respiratory syndrome Severe Acute Respiratory Syndrome Corona Virus suggested susceptibility target therapy treat with COVID-19 [DOI] 10.1186/s12987-022-00357-5 PMC 바로가기 [Article Type] Review
Display of receptor-binding domain of SARS-CoV-2 Spike protein variants on the Saccharomyces cerevisiae cell surfaceArticle Published on 2022-08-122022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome Antibody neutralization antiserum approach B.1.1.7 B.1.351 B.1.617.1 B.1.671.1 Beta binding candidate Cell cellular immune responses coronavirus disease Coronavirus-2 COVID-19 Culture display domain effective enzyme escaped Express Health humoral inducer initial knocked out mutant Neutralizing activity pandemic Protein RBD RBD binding RBDs Receptor-binding domain reduction robust Saccharomyces cerevisiae SARS-CoV-2 SARS-CoV-2 vaccine spike the receptor-binding domain vaccination Vaccine vaccine candidate variant variants wild-type yeast yeast surface display. [DOI] 10.3389/fimmu.2022.935573 PMC 바로가기
Variations of SARS-CoV-2 in the Iranian population and candidate putative drug-like compounds to inhibit the mutated proteinsResearch article Published on 2022-07-112022-10-05 Journal: Heliyon [Category] 신약개발, [키워드] addition Affect antibody appear Ardabil benefit Candidate putative drug-like compounds Ciclesonide complex Compound conserved COVID-19 diagnosing DNA docked element Evolution Frame Genetic Genetic variant help indels indicated inducer Infection inhibit inhibitor Interaction Iran mechanism of action Meta-analysis mutated Mutation Nonstructural proteins (NSPs) Novel coronavirus NSP8 nucleotide nucleotide mutation Open reading frame (ORF) ORF1ab Orf9b Oxford polyproteins Potential Protein reported responsible resveratrol SARS-CoV-2 SARS-CoV-2 gene sequence sequenced Spread Substitution the SARS-CoV-2 Topic treating COVID-19 Vaccine design Viral proteins viral replication virus Wuhan, China [DOI] 10.1016/j.heliyon.2022.e09910 [Article Type] Research article
Immunoinformatic approach for the construction of multi-epitopes vaccine against omicron COVID-19 variant오미크론 COVID-19 변이체에 대한 다중 에피토프 백신 구축을 위한 면역정보학적 접근Article Published on 2022-07-012022-09-11 Journal: Virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] added adjuvant antigenic antigenic epitope antigenic epitopes applied approach B cell epitope B cell epitopes B-cell B.1.1.529 CD4 CD8 chimeric Chimeric vaccine model codon optimization complexes computational tool computational tools concern construction country COVID-19 COVID-19 omicron variant effective epitope Epitopes expression Final flexible Health Organization help highly antigenic Host IFN-γ immune mechanism immunogenic in-silico increasingly inducer initiative linker MEV MHC-II molecular molecular docking molecular dynamics mutagenic N-terminal non-allergenic non-toxic omicron Omicron variant overlapping peptide peptide-based planet Protein reverse vaccinology SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 variant Scientific community Simulation spike Spike protein spike protein. stability suggested T-cell T-cell epitopes TLR TLR2 TLR4 TLRs toxic treat unique vaccination Vaccine vaccine candidate variant VoC WHO World Health Organization [DOI] 10.1016/j.virol.2022.05.001 PMC 바로가기 [Article Type] Article
Physicochemical effect of the N501Y, E484K/Q, K417N/T, L452R and T478K mutations on the SARS-CoV-2 spike protein RBD and its influence on agent fitness and on attributes developed by emerging variants of concernSARS-CoV-2 스파이크 단백질 RBD에 대한 N501Y, E484K/Q, K417N/T, L452R 및 T478K 돌연변이의 물리화학적 효과와 에이전트 적합성 및 우려되는 신흥 변이체에 의해 개발된 속성에 대한 영향Review Published on 2022-07-012022-09-11 Journal: Virology [Category] COVID19(2023년), SARS, 변종, [키워드] addition agent Alter attribute attributes binding caused changes in complex component convalescent sera Effect evade Evolution favor greater immune pressure immunodominant immunogenic induce inducer infection control infection process involved K417N L452R manuscript Mutation mutations N501Y occur Occurrence physicochemical Physicochemical effects Protective antibody RBD Receptor binding domain regions SARS-CoV-2 selective Spike protein spike protein RBD T478K target cells the RBD the SARS-CoV-2 the spike protein therapy Transmissibility turn Vaccine variant Variant of concern. variants of concern Viral transmission virulence virus virus expansion virus genome VoC VOCs [DOI] 10.1016/j.virol.2022.05.003 PMC 바로가기 [Article Type] Review
Discovery and Use of Long dsRNA Mediated RNA Interference to Stimulate Antiviral Protection in Interferon Competent Mammalian Cells인터페론 유능한 포유동물 세포에서 항바이러스 보호를 자극하기 위한 긴 dsRNA 매개 RNA 간섭의 발견 및 사용Article Published on 2022-05-062022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] Antiviral Antiviral effect antiviral response antiviral responses cell line cells cellular cleaved comparable competent complementary Concentration cornerstone CoV dependent on Dicer dsRNA Evidence explanation expressing fluorescent functional gene targeting generate green fluorescent protein HCoV HCoV-229E human coronavirus human coronaviruses IFN immune defense induce inducer inhibit Interference interferons knockdown Lineage Long long dsRNA mammalian mammalian cell mammalian cells Mediated mRNA pathway platform preventing infection produced protection Protein provide required responsible retained RISC RNA RNA interference RNA-induced silencing complex RNAi RNAi pathway SARS-CoV-2 replication sequence shown significantly siRNA siRNAs stimulate stomatitis suppress therapeutic These cells threshold type I interferon vesicular stomatitis vesicular stomatitis virus viral inhibition. virus VSV-GFP [DOI] 10.3389/fimmu.2022.859749 PMC 바로가기 [Article Type] Article
The spike protein of SARS-CoV-2 induces heme oxygenase-1: Pathophysiologic implicationsSARS-CoV-2의 스파이크 단백질은 헴 옥시게나제-1을 유도합니다: 병태생리학적 의미Article Published on 2022-03-012022-09-12 Journal: Biochimica et biophysica acta. Molecular basis of [Category] MERS, SARS, 진단, [키워드] ACE2 Acute kidney injury adaptive AKI angiotensin-converting enzyme 2 assessment caused Cell cell lines cellular clinically COVID-19 COVID-19 patient Effect enzyme examined expression HEK293 heme Heme oxygenase-1 ICAM1 implication induce inducer kidney Kidney injury major organ MCP-1 nephrotoxic outcome overexpressing Plasmid Protective protein expression provide quercetin reduced response SARS-CoV-2 SARS-CoV-2 spike signaling pathway spike Spike protein Spike protein expression syncytia formation syncytia. TNF-α transfected with transfecting upregulate upregulated Urine Vero E6 cell viral spike protein virus was performed [DOI] 10.1016/j.bbadis.2021.166322 PMC 바로가기 [Article Type] Article
Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors새로운 당화 기반 치료제 - 글리옥살라제 1 유도제 및 글리옥살라제 1 억제제Review Published on 2022-02-232022-09-10 Journal: International Journal of Molecular Sciences [Category] 비임상, [키워드] Activation active against aging alleviate apoptotic appear Breast cancer breath cancer chemotherapy Cell cell line Chemotherapy clinical impact clinical trial clinically Combination Complication contribute correction diabetes dicarbonyl stress disease DNA double-blind dysfunction evaluated expression Glioblastoma glioblastoma multiforme Glo1 Glycation glyoxalase hesperetin IMPROVE in vitro in vivo inactivation Increased induce inducer inhibitor insulin insulin resistance low-grade inflammation malaria metabolism methylglyoxal mice multidrug-resistant National Cancer Institute obese outcome outcomes pathogenic Placebo placebo-controlled Protein Proteins prototype Randomized resveratrol SARS-CoV-2 small molecule spliceosome Stress subjects survival therapeutic therapy Treatment Tumor tumor cell line tumors type 2 diabete type 2 diabetes unfolded protein response Vascular [DOI] 10.3390/ijms23052453 PMC 바로가기 [Article Type] Review
Dexamethasone is a dose-dependent perpetrator of drug-drug interactions: implications for use in people living with HIVDexamethasone은 약물-약물 상호작용의 용량 의존적 가해자입니다.Article Published on 2022-02-232022-09-11 Journal: Journal of Antimicrobial Chemotherapy [Category] COVID19(2023년), SARS, 치료제, [키워드] antiretroviral ARV assessment complex Course COVID-19 patient CYP3A4 cytochrome P450 daily dose Dexamethasone dosage dose-dependent drug-drug interaction drugs evaluated implication in vitro in vivo inducer inhibitor inhibitors Interaction management P450 recommendation substrate substrates Treatment victim with HIV [DOI] 10.1093/jac/dkab412 PMC 바로가기 [Article Type] Article